Gemcitabine (elaidate) ( CP-4126; CO-101; Gemcitabine 5'-elaidate )

Catalog No. M23957 CAS No. 210829-30-4

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Datasheet

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Product Name

Gemcitabine (elaidate)
Note

Research use only, not for human use.
Brief Description

Gemcitabine elaidate, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity.?
Description

Gemcitabine elaidate, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity.?Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase.?dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis;?dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
Synonyms

CP-4126; CO-101; Gemcitabine 5'-elaidate
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy;Apoptosis
Research Area

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Indication

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CAS Number

210829-30-4
Formula Weight

527.6
Molecular Formula

C27H43F2N3O5
Purity

>98% (HPLC)
Solubility

DMSO:26 mg/mL (49.28 mM);H2O:< 0.1 mg/mL (insoluble)
SMILES

CCCCCCCC/C=C/CCCCCCCC(OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)C(F)(F)[C@@H]1O)=O
Chemical Name

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